Advanced degrees Master The Master is an advanced university degree. It is modularly structured and normally comprises credits according to the European Credit Transfer System. The Master of Arts MA degree is awarded in the sociological, linguistic and cultural studies programs.
Wednesday, November 14, Scientific Responsible name: However, the nature of motor disorders due to dopaminergic depletion is still being debated. In addition, effective movement control is based on the optimal integration in the Bayesian sense of peripheral sensory signals and predictions of the sensory consequences of movement, supposed to be generated by internal models implemented in the cerebellum.
However, it has been shown that patients with PD have somatosensory deficits, and anatomical and functional cerebellar abnormalities are observed in PD. The understanding of the physiology of the basal ganglia BG network has recently undergone significant development through functional neurosurgery.
Indeed, the implantation of stimulation electrodes in therapeutic GBs represents a unique opportunity to directly record activity within GBs in humans. An exaggerated synchronization of beta oscillations within the BG is recognized as a signature of the PD.
Dopamine medication and deep brain stimulation DBS help normalize beta activity, which correlates with improved motor functions. In agreement with the idea that a deficient output from the BG to the motor system is the main cause of motor disturbances, these regulatory effects have generally been considered in relation to efferent motor signals and examined within the BG-cortex motor loops.
However, our work in healthy adults has shown that the functional roles of beta oscillations in motion control extend well beyond the functions traditionally attributed to the BG-motor cortex network.
Indeed, in the context of motor adaptation tasks, we were able to distinguish several types of beta activities recorded at the cortical level by EEG that are functionally distinct and recruit different neural networks.
In particular, we were able to identify an activity whose modulation pattern and identified sources strongly suggest that it reflects sensory integration and sensorimotor adaptation mechanisms generally associated with cortico-cerebellar loops.
Its main objectives will be to 1 determine whether the different beta activities we have identified in healthy subjects are differentially affected in PD, 2 assess the regulatory effect of dopaminergic medication on each of these activities, as well as the associated behavioural changes, and 3 explore the cortical-subcortical dynamics of each of these different activities.
This project will involve the use of an experimental paradigm in which the visual and proprioceptive conditions of the execution of upper limb movements are altered in a controlled manner, through a robotic device KINARM exoskeleton coupled to a 2D virtual reality system this equipment will be located in the premises of the AP-HM Movement Neurology and Pathology Department.
Two studies are planned, which will be carried out in parallel. Patients implanted for DBS under medication will participate in Study 2, in which we will simultaneously record local field potentials LFP of subthalamic nuclei and EEG activity 6 surface electrodes during the same task as in Study 1.
In his work on electrophysiological data analysis, Antoine Schwey will use a new approach based on the analysis of short oscillation bursts underlying slow modulations of beta power, as well as functional connectivity analysis methods to quantify cotico-subcortical directional interactions.
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